Interference Exploitation-based Hybrid Precoding with Robustness Against Phase Errors

Hybrid analog-digital precoding significantly reduces the hardware costs in massive MIMO transceivers when compared to fully-digital precoding at the expense of increased transmit power. In order to mitigate the above shortfall, we use the concept of constructive interference-based precoding, which has been shown to offer significant transmit power savings when compared with the conventional interference suppression-based precoding in fully-digital multiuser MIMO systems. Moreover, in order to circumvent the potential quality-of-service degradation at the users due to the hardware impairments in the transmitters, we judiciously incorporate robustness against such vulnerabilities in the precoder design. Since the undertaken constructive interference-based robust hybrid precoding problem is nonconvex with infinite constraints and thus difficult to solve optimally, we decompose the problem into two subtasks, namely, analog precoding and digital precoding. In this paper, we propose an algorithm to compute the optimal constructive interference-based robust digital precoders. Furthermore, we devise a scheme to facilitate the implementation of the proposed algorithm in a low-complexity and distributed manner. We also discuss block-level analog precoding techniques. Simulation results demonstrate the superiority of the proposed algorithm and its implementation scheme over the state-of-the-art methods

Energy-Efficient and Robust Hybrid Analog-Digital Precoding for Massive MIMO Systems

The fifth-generation (5G) and future cellular networks are expected to facilitate wireless communication among tens of billions of devices with enormously high data rate and ultra-high reliability. At the same time, these networks are required to embrace green technology by significantly improving the energy efficiency of wireless communication to reduce their carbon footprint. The massive multiple-input multiple-output (MIMO) systems, in which the base stations are equipped with hundreds of antenna elements, can provide immensely high data rates and support a large number of users by employing the precoding at the base stations. However, the conventional precoding techniques - which require a dedicated radio-frequency chain for each antenna element - become prohibitively expensive for massive MIMO systems. To address this shortcoming, the hybrid analog-digital precoding architecture is proposed, which requires fewer radio-frequency chains than the antenna elements. The reduced hardware costs in this novel architecture, however, comes at the expense of reduced degrees of freedom for the precoding, which deteriorates the energy efficiency of the network. In this thesis, we consider the design of energy-efficient hybrid precoding techniques in multiuser downlink massive MIMO systems. These systems are fundamentally interference limited. To mitigate the interference, we adopt two interference management strategies while designing the hybrid precoding schemes. They are, namely, interference suppression-based hybrid precoding, and interference exploitation-based hybrid precoding. The former approach results in a lower computational complexity - as the resulting precoders remain the same as long as the channel is unchanged when compared to the latter approach. On the other hand, the interference exploitation-based hybrid precoding is more energy efficient due to judicious use of transmit symbol information, as compared to the interference suppression-based hybrid precoding. In the hybrid analog-digital precoding, analog precoders are implemented in analog radio-frequency domain using a large number of phase shifters, which are relatively inexpensive. These phase shifters, however, typically suffer from artifacts; their actual values differ from their nominal values. These imperfect phase shifters can lead to symbol estimation errors at the users, which may not be tolerable in many applications of future cellular networks. To establish a high-reliable communication under the plight of imperfect phase shifters in the hybrid precoding architecture, in this thesis, we propose an energy-efficient, robust hybrid precoding technique. The designed scheme guarantees 100% robustness against the considered hardware artifacts. Moreover, the thesis demonstrates that the proposed technique can save up to 12% transmit power when compared to a conventional method. Another critically important requirement of the future cellular networks - apart from ultra-high reliability and energy efficiency - is ultra-low latency. Some envisioned extreme real-time applications of 5G, such as autonomous driving and remote surgery, demand an end-to-end latency smaller than one millisecond. To fulfill such a stringent demand, we devise an efficient implementation scheme for the proposed robust hybrid precoding technique to reduce the required computational time. The devised scheme exploits special structures present in the algorithm to reduce the computational complexity and can compute the precoders in a distributed manner on a parallel hardware architecture. The results show that the proposed implementation scheme can reduce the average computation time of the algorithm by 35% when compared to a state-of-the-art method. Finally, we consider the hybrid precoding in heterogeneous networks, where the cell edge users typically experience severe interference. We propose a coordinated hybrid precoding technique based on the interference exploitation approach. The numerical results reveal that the proposed coordinated hybrid precoding results in a significant transmit power savings when compared to the uncoordinated hybrid precoding

Joint Antenna Selection and Phase-Only Beamforming Using Mixed-Integer Nonlinear Programming

In this paper, we consider the problem of joint antenna selection and analog beamformer design in downlink single-group multicast networks. Our objective is to reduce the hardware costs by minimizing the number of required phase shifters at the transmitter while fulfilling given distortion limits at the receivers. We formulate the problem as an L0 minimization problem and devise a novel branch-and-cut based algorithm to solve the resulting mixed-integer nonlinear program to optimality. We also propose a suboptimal heuristic algorithm to solve the above problem approximately with a low computational complexity. Computational results illustrate that the solutions produced by the proposed heuristic algorithm are optimal in most cases. The results also indicate that the performance of the optimal methods can be significantly improved by initializing with the result of the suboptimal method.Comment: to be presented at WSA 201

Pleomorphic Adenoma of the Hard Palate:A Multidisciplinary Approach

Pleomorphic adenoma is the most common salivary gland tumor accounting for 80% of all major salivary gland tumors. It is a benign salivary gland neoplasm that constitutes 3% to 10% of the neoplasms in the head and neck region.1 Salivary gland neoplasms represents less than 1% of all tumors. This article is being showcased as a special case due to the fact it was done at a Taluk Hospital and also because ENT and oromaxillofacial surgeons were involved during the surgery

Residual tumor cells that drive disease relapse after chemotherapy do not have enhanced tumor initiating capacity.

Although chemotherapy is used to treat most advanced solid tumors, recurrent disease is still the major cause of cancer-related mortality. Cancer stem cells (CSCs) have been the focus of intense research in recent years because they provide a possible explanation for disease relapse. However, the precise role of CSCs in recurrent disease remains poorly understood and surprisingly little attention has been focused on studying the cells responsible for re-initiating tumor growth within the original host after chemotherapy treatment. We utilized both xenograft and genetically engineered mouse models of non-small cell lung cancer (NSCLC) to characterize the residual tumor cells that survive chemotherapy treatment and go on to cause tumor regrowth, which we refer to as tumor re-initiating cells (TRICs). We set out to determine whether TRICs display characteristics of CSCs, and whether assays used to define CSCs also provide an accurate readout of a cell's ability to cause tumor recurrence. We did not find consistent enrichment of CSC marker positive cells or enhanced tumor initiating potential in TRICs. However, TRICs from all models do appear to be in EMT, a state that has been linked to chemoresistance in numerous types of cancer. Thus, the standard CSC assays may not accurately reflect a cell's ability to drive disease recurrence

Neural stem cell properties of Müller glia in the mammalian retina: Regulation by Notch and Wnt signaling

AbstractThe retina in adult mammals, unlike those in lower vertebrates such as fish and amphibians, is not known to support neurogenesis. However, when injured, the adult mammalian retina displays neurogenic changes, raising the possibility that neurogenic potential may be evolutionarily conserved and could be exploited for regenerative therapy. Here, we show that Müller cells, when retrospectively enriched from the normal retina, like their radial glial counterparts in the central nervous system (CNS), display cardinal features of neural stem cells (NSCs), i.e., they self-renew and generate all three basic cell types of the CNS. In addition, they possess the potential to generate retinal neurons, both in vitro and in vivo. We also provide direct evidence, by transplanting prospectively enriched injury-activated Müller cells into normal eye, that Müller cells have neurogenic potential and can generate retinal neurons, confirming a hypothesis, first proposed in lower vertebrates. This potential is likely due to the NSC nature of Müller cells that remains dormant under the constraint of non-neurogenic environment of the adult normal retina. Additionally, we demonstrate that the mechanism of activating the dormant stem cell properties in Müller cells involves Wnt and Notch pathways. Together, these results identify Müller cells as latent NSCs in the mammalian retina and hence, may serve as a potential target for cellular manipulation for treating retinal degeneration

Energy-Efficient and Robust Hybrid Analog-Digital Precoding for Massive MIMO Systems

The fifth-generation (5G) and future cellular networks are expected to facilitate wireless communication among tens of billions of devices with enormously high data rate and ultra-high reliability. At the same time, these networks are required to embrace green technology by significantly improving the energy efficiency of wireless communication to reduce their carbon footprint. The massive multiple-input multiple-output (MIMO) systems, in which the base stations are equipped with hundreds of antenna elements, can provide immensely high data rates and support a large number of users by employing the precoding at the base stations. However, the conventional precoding techniques - which require a dedicated radio-frequency chain for each antenna element - become prohibitively expensive for massive MIMO systems. To address this shortcoming, the hybrid analog-digital precoding architecture is proposed, which requires fewer radio-frequency chains than the antenna elements. The reduced hardware costs in this novel architecture, however, comes at the expense of reduced degrees of freedom for the precoding, which deteriorates the energy efficiency of the network. In this thesis, we consider the design of energy-efficient hybrid precoding techniques in multiuser downlink massive MIMO systems. These systems are fundamentally interference limited. To mitigate the interference, we adopt two interference management strategies while designing the hybrid precoding schemes. They are, namely, interference suppression-based hybrid precoding, and interference exploitation-based hybrid precoding. The former approach results in a lower computational complexity - as the resulting precoders remain the same as long as the channel is unchanged when compared to the latter approach. On the other hand, the interference exploitation-based hybrid precoding is more energy efficient due to judicious use of transmit symbol information, as compared to the interference suppression-based hybrid precoding. In the hybrid analog-digital precoding, analog precoders are implemented in analog radio-frequency domain using a large number of phase shifters, which are relatively inexpensive. These phase shifters, however, typically suffer from artifacts; their actual values differ from their nominal values. These imperfect phase shifters can lead to symbol estimation errors at the users, which may not be tolerable in many applications of future cellular networks. To establish a high-reliable communication under the plight of imperfect phase shifters in the hybrid precoding architecture, in this thesis, we propose an energy-efficient, robust hybrid precoding technique. The designed scheme guarantees 100% robustness against the considered hardware artifacts. Moreover, the thesis demonstrates that the proposed technique can save up to 12% transmit power when compared to a conventional method. Another critically important requirement of the future cellular networks - apart from ultra-high reliability and energy efficiency - is ultra-low latency. Some envisioned extreme real-time applications of 5G, such as autonomous driving and remote surgery, demand an end-to-end latency smaller than one millisecond. To fulfill such a stringent demand, we devise an efficient implementation scheme for the proposed robust hybrid precoding technique to reduce the required computational time. The devised scheme exploits special structures present in the algorithm to reduce the computational complexity and can compute the precoders in a distributed manner on a parallel hardware architecture. The results show that the proposed implementation scheme can reduce the average computation time of the algorithm by 35% when compared to a state-of-the-art method. Finally, we consider the hybrid precoding in heterogeneous networks, where the cell edge users typically experience severe interference. We propose a coordinated hybrid precoding technique based on the interference exploitation approach. The numerical results reveal that the proposed coordinated hybrid precoding results in a significant transmit power savings when compared to the uncoordinated hybrid precoding